Serum Creatinine and Cystatin-C Levels in Patients Diagnosed with Kidney Disorders
DOI:
https://doi.org/10.61843/jondpac.v1i2.631Keywords:
Noncommunicable diseases, Kidney disorders, Serum creatinine, Cystatin-C, Renal function examination, Penyakit tidak menular, Gangguan ginjal, Kreatinin serum, Pemeriksaan fungsi ginjalAbstract
The development of non-communicable diseases still dominates in Indonesia. One of them is kidney failure, which contributes to the burden of disease in the world with a fairly high death rate. Examination parameters to indicate renal condition can be seen from several laboratory examination results, such as levels of creatinine, urea, cystatin-C, uric acid, microalbuminuria, and others. The aim of this study is to obtain a brief overview of creatinine and cystatin-C levels in patients diagnosed with kidney disorders to determine the extent of the severity of the disease that has occurred. The method used in this research is descriptive analysis with laboratory examination using a cross-sectional approach. The number of samples in this research was 30. Based on the research results, respondents were dominated by women (53.3%) with an age range of 28–76 years. The proportion of respondents' creatinine levels was still more in the normal category, and the proportion exceeding the normal limit for male and female respondent groups was the same, namely 50% each. Meanwhile, the cystatin-C levels of respondents were more often found in the above-normal category (63.3%), which was dominated by the group of female respondents (57.9%).
Downloads
References
Andersson, A., Hansson, E., Ekström, U., Grubb, A., Abrahamson, M., Jakobsson, K., & Xu, Y. (2022). Large difference but high correlation between creatinine and cystatin C estimated glomerular filtration rate in Mesoamerican sugarcane cutters. Occupational and Environmental Medicine, 79(7), 497-502.
Anggraini, D. (2022). Aspek Klinis Dan Pemeriksaan Laboratorium Penyakit Ginjal Kronik. An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal), 9(2), 236-239.
Arifin, H., Chou, K. R., Ibrahim, K., Fitri, S. U. R. A., Pradipta, R. O., Rias, Y. A., ... & Pahria, T. (2022). Analysis of Modifiable, Non-Modifiable, and Physiological Risk Factors of Non-Communicable Diseases in Indonesia: Evidence from the 2018 Indonesian Basic Health Research. Journal of Multidisciplinary Healthcare, 2203-2221. https://doi.org/10.2147/JMDH.S382191
Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. (2019). Laporan Riset Kesehatan Dasar Tahun 2018. Kementerian Kesehatan RI.
Benoit, S. W., Ciccia, E. A., & Devarajan, P. (2020). Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert review of molecular diagnostics, 20(10), 1019–1026. https://doi.org/10.1080/14737159.2020.1768849
Chaudhary, S. S., Shah, J. P., & Mahato, R. V. (2015). Interference of bilirubin in creatinine value measurement by Jaffe kinetic method. Annals of Clinical Chemistry and Laboratory Medicine, 1(1), 25-28.
Ciin, M. N., Proungvitaya, T., Limpaiboon, T., Roytrakul, S., Cha’on, U., Tummanatsakun, D., & Proungvitaya, S. (2020). Serum cystatin C as a potential marker for glomerular filtration rate in patients with cholangiocarcinoma. International Journal of Hematology-Oncology and Stem Cell Research, 14(3), 157.
Dewi, J. (2013). Cystatin C, HbA1c, dan Rasio Albumin Kreatinin. Indonesian Journal of Clinical Pathology and Medical Laboratory, 19(3), 167-173.
Kang, E., Han, S. S., Kim, J., Park, S. K., Chung, W., Oh, Y. K., ... & Oh, K. H. (2020). Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort. BMC nephrology, 21(1), 1-9.
Kovesdy, C. P. (2022). Epidemiology of chronic kidney disease: an update 2022. Kidney International Supplements, 12(1), 7-11.
Massey, D. (2004). Commentary: clinical diagnostic use of cystatin C. Journal of clinical laboratory analysis, 18(1), 55-60.
Nigam, P. K. (2016). Bilirubin interference in serum creatinine estimation by Jaffe’s kinetic method and its rectification in three different kits. Indian Journal of Clinical Biochemistry, 31, 237-239.
Raj, G. V., Iasonos, A., Herr, H., & Donat, S. M. (2006). Formulas calculating creatinine clearance are inadequate for determining eligibility for cisplatin-based chemotherapy in bladder cancer. Journal of Clinical Oncology, 24(19), 3095-3100.
Sjöström, P., Tidman, M., & Jones, I. (2005). Determination of the production rate and non‐renal clearance of cystatin C and estimation of the glomerular filtration rate from the serum concentration of cystatin C in humans. Scandinavian journal of clinical and laboratory investigation, 65(2), 111-124.
Wantania, J., & Winarto, A. (2018). The comparison of creatinine and cystatin C value in preeclampsia severity and neonatal outcome. Majalah Obstetri dan Ginekologi, 24(3), 84-89.
Wardhani, F. M., Chiuman, L., Novalinda Ginting, C., & Ginting, S. F. (2020). Role of cystatin-C as serum biomarkers in predicting glomerular function associated with copper-induced acute kidney injury. Majalah Kedokteran Bandung, 52(1), 16-21.
World Health Organization. (2018). Noncommunicable Diseases Country Profiles 2018. World Health Organization.
Downloads
Published
How to Cite
Issue
Section
License
The Journal of Noncommunicable Diseases Prevention and Control applies the Creative Commons Attribution 4.0 International (CC BY) License, or other comparable licenses that allow free and unrestricted use to articles we publish. If you submit your manuscript for publication by the Journal of Noncommunicable Diseases Prevention and Control, you agree to have the CC BY license applied to your work. If your institution or funder requires your work or materials to be published under a different license or dedicated to the public domain - for example, Creative Commons 1.0 Universal (CC0) or Open Governmental License - this is permitted for those licenses where the terms are equivalent to or more permissive than CC BY.